IGN has a new interview as well as a new video of the upcoming Wii game Monster Lab where you get to step into the shoes of a mad scientist and create your own monsters and have them fight. The gameplay is supposed to be a lot deeper than that, and there's even online multiplayer.
You start off as an apprentice in the Mad Science Alliance. You learn (with help from your mentor, Professor Fuseless) how to explore six different areas of the Ghastly Valley in order to find different ingredients. Once you have those, you take them back to your castle in order to perform experiments, using the ingredients. Those then make different monster parts (heads, torsos, arms, and legs), based on three different sciences (mechanical, alchemical, and biological) There are literally millions of different combinations of monsters you can make. You then take control of your monster to go back out in to the world to progress through the game, battling other monsters along the way! - Kelly Tainton
There apparently is a large mini-game component which is worrying, but given the quality I've seen so far I'm willing to give these guys the benefit of the doubt. Hopefully this will turn out to be another quality Wii title. Check out the interview and movie over at IGN.